Many families are finding ways to support their children through nutrition and gentle supplementation. This guide explains some of
the most researched and parent-reported supports, simplified for everyday understanding. Each child is unique — the goal is to
empower parents with knowledge to discuss options confidently with healthcare providers.
- Leucovorin (Prescription Folinic Acid)
Leucovorin is a prescription form of folinic acid used to support children who may have trouble processing folate properly. Research suggests it
may help improve language, attention, and social connection in some children with autism.
Typical Dosage: 0.5–2 mg/kg/day for children (divided in two doses); 15–30 mg twice daily for teens.
Parent Tip: Ask your doctor about folate receptor antibody (FRAA) testing before starting.
- Folinic Acid (Over-the-Counter Support)
Folinic acid is the over-the-counter version of Leucovorin. It supports healthy methylation and brain energy. Parents report it helps with focus
and mood when used consistently under supervision.
Typical Dosage: Children: 400 mcg – 10 mg daily; Teens: 10–30 mg daily.
Parent Tip: Always start low and increase slowly to watch for responses.
- Vitamin B12 (Methylcobalamin or Hydroxocobalamin)
Vitamin B12 supports speech, focus, and energy by improving methylation — a key biochemical process in the body. It can be given orally or
through injections, depending on what your provider recommends.
Typical Dosage: 250–2000 mcg orally or by injection 2–3 times per week.
Parent Tip: Some children respond better to injectable forms than oral ones.
- Dairy-Free Options
Removing dairy (casein) may help reduce gut irritation and behavioral changes in some sensitive children. Families often notice better digestion
and calmness after switching to non-dairy options.
Parent Tip: Try milk alternatives such as almond, oat, or coconut milk, and dairy-free cheese or yogurt.
- Calming & Focus Support
Some supplements may temporarily increase energy or hyperactivity. Pairing them with natural calming supports helps balance mood and sleep.
Natural Calming Supports:
• Magnesium glycinate (50–200 mg depending on age)
• L-theanine (gentle amino acid)
• Chamomile or lemon balm tea
• Omega-3 fatty acids for mood balance
Parent Tip: Try calming supports with dinner or before bedtime.
References & Important Notes
• These dosages are based on parent reports and clinical studies. Always consult a licensed healthcare provider before starting or changing
supplements.
References:
- Frye, R. E. et al. (2013). Folate receptor autoantibodies in autism spectrum disorders. Molecular Psychiatry.
- James, S. J. et al. (2009). Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in autism. Am. J. Clin. Nutr.
- Adams, J. B., et al. (2018). Comprehensive nutritional and metabolic treatment for autism spectrum disorder: A randomized, controlled
12-month trial. Nutrients - Frye, R. E. (2024). Instagram insights: Understanding Leucovorin and Brain Folate in Autism. @dr.richardfrye
About Ali’s Gift Health Initiative Foundation
Ali’s Gift Health Initiative Foundation is dedicated to empowering families through education, advocacy, and autism awareness. We believe
every child deserves understanding, inclusion, and a pathway to their fullest potential. Through community outreach and educational resources,
we help families thrive with hope and science combined.